abstract：AIMS:To investigate the ability of SYNTAX score and Clinical SYNTAX score (CSS) to predict very long-term outcomes in an all-comers population receiving drug-eluting stents. METHODS AND RESULTS:The SYNTAX score was retrospectively calculated in 848 patients enrolled in the SIRolimus-eluting stent compared with pacliTA...

journal_title：European heart journal

authors： Girasis C,Garg S,Räber L,Sarno G,Morel MA,Garcia-Garcia HM,Lüscher TF,Serruys PW,Windecker S

更新日期：2011-12-01 00:00:00

abstract：:AIMS Pre-treatment with clopidogrel results in a reduction of ischaemic events in non-ST-elevation acute coronary syndromes. Data on upstream clopidogrel in the setting of primary percutaneous coronary intervention (PCI) are limited. The aim of this study was to investigate whether clopidogrel loading before arrival a...

journal_title：European heart journal

authors： Dörler J,Edlinger M,Alber HF,Altenberger J,Benzer W,Grimm G,Huber K,Pachinger O,Schuchlenz H,Siostrzonek P,Zenker G,Weidinger F,Austrian Acute PCI Investigators.

更新日期：2011-12-01 00:00:00

abstract：AIMS:A potential role for cardiovascular disease (CVD) risk factors in the aetiology of suicide has not been comprehensively examined. In addition to being small in scale and poorly characterized, existing studies very rarely sample Asian populations in whom risk factor-suicide relationships may plausibly differ to Cau...

journal_title：European heart journal

authors： Jee SH,Kivimaki M,Kang HC,Park IS,Samet JM,Batty GD

更新日期：2011-11-01 00:00:00

abstract：AIMS:Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance of FAP in thin-cap human fibroatheromata remains unknown. METHOD...

journal_title：European heart journal

authors： Brokopp CE,Schoenauer R,Richards P,Bauer S,Lohmann C,Emmert MY,Weber B,Winnik S,Aikawa E,Graves K,Genoni M,Vogt P,Lüscher TF,Renner C,Hoerstrup SP,Matter CM

更新日期：2011-11-01 00:00:00

abstract：AIMS:The Pacing to Avoid Cardiac Enlargement (PACE) trial is a prospective, double-blinded, randomized, multicentre study that reported the superiority of biventricular (BiV) pacing to right ventricular apical (RVA) pacing in the prevention of left ventricular (LV) adverse remodelling and deterioration of systolic func...

journal_title：European heart journal

authors： Chan JY,Fang F,Zhang Q,Fung JW,Razali O,Azlan H,Lam KH,Chan HC,Yu CM

更新日期：2011-10-01 00:00:00

abstract：:The optimal length of clopidogrel therapy in patients with acute coronary syndromes or in those who have undergone percutaneous coronary intervention (PCI) remains controversial. We therefore sought to determine the risk of both perioperative and premature discontinuation of clopidogrel. PubMed and EMBASE databases we...

journal_title：European heart journal

authors： Gaglia MA Jr,Waksman R

更新日期：2011-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is cur...

journal_title：European heart journal

authors： Lau EM,Manes A,Celermajer DS,Galiè N

更新日期：2011-10-01 00:00:00

abstract：AIMS:Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. METHODS AND RESULTS:We identified 28,637 pa...

journal_title：European heart journal

authors： Emilsson L,Smith JG,West J,Melander O,Ludvigsson JF

更新日期：2011-10-01 00:00:00

abstract：:MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain re...

journal_title：European heart journal

authors： Rogers JH,Franzen O

更新日期：2011-10-01 00:00:00

abstract：AIMS:The aim of this study was to determine the outcome benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-8 years after closure of the lipid-lowering arm (LLA) of the trial (ASCOT-LLA) among the U.K. population. METHODS AND RESULTS:ASCOT-LLA was a factorially designed ...

journal_title：European heart journal

authors： Sever PS,Chang CL,Gupta AK,Whitehouse A,Poulter NR,ASCOT Investigators.

更新日期：2011-10-01 00:00:00

abstract：AIMS:Various definitions of major bleeding have been used to evaluate safety in randomized controlled trials of antiplatelet therapy. We compared the definitions and rates of major bleeding in phase III randomized controlled trials of oral P2Y(12) inhibitors in the management of patients with acute coronary syndromes (...

journal_title：European heart journal

authors： Quinlan DJ,Eikelboom JW,Goodman SG,Welsh RC,Fitchett DH,Théroux P,Mehta SR

更新日期：2011-09-01 00:00:00

abstract：AIMS:Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXU...

journal_title：European heart journal

authors： Kappetein AP,Feldman TE,Mack MJ,Morice MC,Holmes DR,Ståhle E,Dawkins KD,Mohr FW,Serruys PW,Colombo A

更新日期：2011-09-01 00:00:00

abstract：AIMS:Although inflammation contributes to cardiovascular disease, the associations of appendectomy and tonsillectomy, which remove mucosa-associated lymphoid tissue, with risk of acute myocardial infarction (AMI) are unknown. Our aim was to assess the association between these operations performed in childhood and AMI ...

journal_title：European heart journal

authors： Janszky I,Mukamal KJ,Dalman C,Hammar N,Ahnve S

更新日期：2011-09-01 00:00:00

abstract：:After years of stagnant finances for research, moves are under way to increase research funds in Europe. ...

journal_title：European heart journal

authors： Smith U,Sipido K,Dive C,Nicod L

更新日期：2011-09-01 00:00:00

abstract：AIMS:Coronary artery calcium (CAC) scoring has emerged as a tool for risk stratification and potentially for monitoring response to risk factor modification. Therefore, repeat measurements should provide robust results and low inter-scanner variability for allowing meaningful comparison. The purpose of this study was t...

journal_title：European heart journal

authors： Ghadri JR,Goetti R,Fiechter M,Pazhenkottil AP,Küest SM,Nkoulou RN,Windler C,Buechel RR,Herzog BA,Gaemperli O,Templin C,Kaufmann PA

更新日期：2011-08-01 00:00:00

abstract：AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and functio...

journal_title：European heart journal

authors： Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M

更新日期：2011-08-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate the effect of valve surgery (VS) in infective endocarditis (IE) on 5-year mortality and to evaluate whether conflicting results reported by previous studies could be due to differences in their methodological approaches. METHODS AND RESULTS:Four hundred and forty-nine patient...

journal_title：European heart journal

authors： Bannay A,Hoen B,Duval X,Obadia JF,Selton-Suty C,Le Moing V,Tattevin P,Iung B,Delahaye F,Alla F,AEPEI Study Group.

更新日期：2011-08-01 00:00:00

abstract：:The diagnosis and management of patients with renovascular disease and hypertension continue to elude healthcare providers. The advent of novel imaging and interventional techniques, and increased understanding of the pathways leading to irreversible renal injury and renovascular hypertension, have ushered in commenda...

journal_title：European heart journal

authors： Baumgartner I,Lerman LO

更新日期：2011-07-01 00:00:00

abstract：AIMS:Previous trials that investigated cell therapy as an adjunctive therapy after acute myocardial infarction (AMI) have shown conflicting results. We designed a randomized controlled trial to determine the effect of intracoronary infusion of mononuclear cells from bone marrow (BM) or peripheral blood in patients with...

journal_title：European heart journal

authors： Hirsch A,Nijveldt R,van der Vleuten PA,Tijssen JG,van der Giessen WJ,Tio RA,Waltenberger J,ten Berg JM,Doevendans PA,Aengevaeren WR,Zwaginga JJ,Biemond BJ,van Rossum AC,Piek JJ,Zijlstra F,HEBE Investigators.

更新日期：2011-07-01 00:00:00

abstract：:Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wireles...

journal_title：European heart journal

authors： Hasan A,Paul V

更新日期：2011-06-01 00:00:00

abstract：:It may be diagnosing Thalassaemia with magnetic resonance, navigating catheters round tight corners with magnets, or treating Marfan's syndrome with the Brompton Sheath--but if it is state of the art and it works, the Royal Brompton & Harefield NHS Foundation Trust, London, will almost certainly have pioneered it, rep...

journal_title：European heart journal

authors：

更新日期：2011-06-01 00:00:00

abstract：:A recent report of the EuroHeart project has shown that women are still underrepresented in many cardiovascular clinical trials, while important gender differences are present within most areas of heart disease. As the burden of cardiovascular disease is increasing in middle-aged women relative to men, a more profound...

journal_title：European heart journal

authors： Maas AH,van der Schouw YT,Regitz-Zagrosek V,Swahn E,Appelman YE,Pasterkamp G,Ten Cate H,Nilsson PM,Huisman MV,Stam HC,Eizema K,Stramba-Badiale M

更新日期：2011-06-01 00:00:00

abstract：AIMS:Major guidelines recommend lowering systolic blood pressure (SBP) to <140 mmHg in all hypertensives, but evidence is missing whether this is beneficial in (i) uncomplicated hypertensives, (ii) grade 1 hypertensives, and (iii) elderly hypertensives. Providing this missing evidence is important to justify efforts an...

journal_title：European heart journal

authors： Zhang Y,Zhang X,Liu L,Zanchetti A,FEVER Study Group.

更新日期：2011-06-01 00:00:00

abstract：AIMS:To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). METHODS AND RESULTS:A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were in...

journal_title：European heart journal

authors： Ng AC,Delgado V,Bertini M,Antoni ML,van Bommel RJ,van Rijnsoever EP,van der Kley F,Ewe SH,Witkowski T,Auger D,Nucifora G,Schuijf JD,Poldermans D,Leung DY,Schalij MJ,Bax JJ

更新日期：2011-06-01 00:00:00

abstract：AIMS:Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been reported. We present, for the first time, a novel loss-of-function mu...

journal_title：European heart journal

authors： Templin C,Ghadri JR,Rougier JS,Baumer A,Kaplan V,Albesa M,Sticht H,Rauch A,Puleo C,Hu D,Barajas-Martinez H,Antzelevitch C,Lüscher TF,Abriel H,Duru F

更新日期：2011-05-01 00:00:00

abstract：AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Pro...

journal_title：European heart journal

authors： Crowe FL,Roddam AW,Key TJ,Appleby PN,Overvad K,Jakobsen MU,Tjønneland A,Hansen L,Boeing H,Weikert C,Linseisen J,Kaaks R,Trichopoulou A,Misirli G,Lagiou P,Sacerdote C,Pala V,Palli D,Tumino R,Panico S,Bueno-de-Mesqu

更新日期：2011-05-01 00:00:00

abstract：AIMS:To investigate the effects of secretory phospholipase A2 (sPLA(2)) inhibition on plasma lipoproteins. Secretory phospholipase A2 isoenzymes promote atherosclerosis by mechanisms that include lipoprotein modification, retention, and oxidation. METHODS AND RESULTS:Phospholipase Levels And Serological Markers of Ath...

journal_title：European heart journal

authors： Rosenson RS,Elliott M,Stasiv Y,Hislop C,PLASMA II Investigators.

更新日期：2011-04-01 00:00:00

abstract：AIMS:Cardiomyopathy produces significant mortality in patients with Friedreich ataxia (FA), a genetic disorder that produces intra-mitochondrial iron accumulation. We sought to test the hypothesis that abnormal myocardial perfusion reserve and fibrosis represent early manifestations of cardiomyopathy. METHODS AND RESU...

journal_title：European heart journal

authors： Raman SV,Phatak K,Hoyle JC,Pennell ML,McCarthy B,Tran T,Prior TW,Olesik JW,Lutton A,Rankin C,Kissel JT,Al-Dahhak R

更新日期：2011-03-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is associated with abnormal sarcoplasmic reticulum (SR) calcium release, which is promoted by adenosine A(2A) receptor (A(2A)R) activation. Here, we tested the hypothesis that abnormal calcium release in AF is linked to A(2A)R remodelling. METHODS AND RESULTS:Western blotting and quantita...

journal_title：European heart journal

authors： Llach A,Molina CE,Prat-Vidal C,Fernandes J,Casadó V,Ciruela F,Lluís C,Franco R,Cinca J,Hove-Madsen L

更新日期：2011-03-01 00:00:00

abstract：AIMS:In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding is unknown. We therefore sought to examine the prognostic value of elevated troponin I in patients with atrial fibrillation. METHODS AND RESULTS:A prospective study was cond...

journal_title：European heart journal

authors： van den Bos EJ,Constantinescu AA,van Domburg RT,Akin S,Jordaens LJ,Kofflard MJ

更新日期：2011-03-01 00:00:00

abstract：AIMS:The aim of this study is to simultaneously evaluate the incremental prognostic value of multiple cardiac biomarkers reflecting different underlying pathophysiological processes in a well-characterized population of patients with non-ST-segment acute coronary syndrome (NSTE-ACS). METHODS AND RESULTS:We measured ca...

journal_title：European heart journal

authors： Scirica BM,Sabatine MS,Jarolim P,Murphy SA,de Lemos JL,Braunwald E,Morrow DA

更新日期：2011-03-01 00:00:00

abstract：AIMS:In patients with sick sinus syndrome, bradycardia can be treated with a single-lead pacemaker or a dual-chamber pacemaker. Previous trials have revealed that pacing modes preserving atrio-ventricular synchrony are superior to single-lead ventricular pacing, but it remains unclear if there is any difference between...

journal_title：European heart journal

authors： Nielsen JC,Thomsen PE,Højberg S,Møller M,Vesterlund T,Dalsgaard D,Mortensen LS,Nielsen T,Asklund M,Friis EV,Christensen PD,Simonsen EH,Eriksen UH,Jensen GV,Svendsen JH,Toff WD,Healey JS,Andersen HR,DANPACE Investigato

更新日期：2011-03-01 00:00:00

abstract：:The cytokine hypothesis presently suggests that an excessive production of pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF) and interleukin 6 (IL6), contributes to the pathogenesis of heart failure. The concept, successfully proved in genetically modified animal models, failed to translate to hum...

journal_title：European heart journal

authors： Lecour S,James RW

更新日期：2011-03-01 00:00:00

abstract：AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

journal_title：European heart journal

authors： Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

更新日期：2011-02-01 00:00:00

abstract：AIMS:Migration, urbanization, and change in socio-economic factors have potentially profound effects on heart disease in low-to-middle income countries. METHODS AND RESULTS:Chris Hani Baragwanath Hospital in Soweto, South Africa, provides health care to >1 million Africans. We systematically captured data from all de ...

journal_title：European heart journal

authors： Stewart S,Carrington M,Pretorius S,Methusi P,Sliwa K

更新日期：2011-02-01 00:00:00

abstract：AIMS:The aim of this study was to determine the contribution of physical activity and abdominal obesity to the variation in inflammatory biomarkers and incident coronary heart disease (CHD) in a European population. METHODS AND RESULTS:In a prospective case-control study nested in the European Prospective Investigatio...

journal_title：European heart journal

authors： Rana JS,Arsenault BJ,Després JP,Côté M,Talmud PJ,Ninio E,Wouter Jukema J,Wareham NJ,Kastelein JJ,Khaw KT,Boekholdt SM

更新日期：2011-02-01 00:00:00

abstract：AIMS:Resuscitated cardiac arrest (CA), leading to harmful cardiovascular dysfunction and multiple organ failure, includes a whole-body hypoxia-reoxygenation phenomenon. Opening of the mitochondrial permeability transition pore (mPTP) appears to be a pivotal event in ischaemia-reperfusion injury. We hypothesized that ph...

journal_title：European heart journal

authors： Cour M,Loufouat J,Paillard M,Augeul L,Goudable J,Ovize M,Argaud L

更新日期：2011-01-01 00:00:00

abstract：:A twenty-first century model for the training and assessment of cardiac interventionists’ skills, outlined by Prof. John Morgan FRCP FESC. ...

journal_title：European heart journal

authors： Morgan JM,Burri H,Binner L,Mansour H,Retzlaff H,Roca M,Gallagher A

更新日期：2011-01-01 00:00:00

abstract：AIMS:Patients with chronic kidney disease (CKD) pose a worldwide growing burden to health care systems due to accelerated atherosclerosis and subsequent high cardiovascular (CV) morbidity. Atherogenesis is prominently driven by monocytes and monocyte-derived macrophages. The expression of CD14 and CD16 characterizes th...

journal_title：European heart journal

authors： Rogacev KS,Seiler S,Zawada AM,Reichart B,Herath E,Roth D,Ulrich C,Fliser D,Heine GH

更新日期：2011-01-01 00:00:00

abstract：AIMS:in hypertrophic cardiomyopathy (HCM), the following five risk factors have a major role in the primary prevention of sudden death (SD): family history of SD (FHSD), syncope, massive wall thickness (MWTh) >30 mm, non-sustained ventricular tachycardia (nsVT) in Holter monitoring of electrocardiography, and abnormal ...

journal_title：European heart journal

authors： Dimitrow PP,Chojnowska L,Rudzinski T,Piotrowski W,Ziólkowska L,Wojtarowicz A,Wycisk A,Dabrowska-Kugacka A,Nowalany-Kozielska E,Sobkowicz B,Wróbel W,Aleszewicz-Baranowska J,Rynkiewicz A,Loboz-Grudzien K,Marchel M,Wysokinski

更新日期：2010-12-01 00:00:00